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The Great Resignation

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MegaL †Mirror

Humans are capable of extracting spatial information through their sense of touch: when someone strokes their hand, they can easily determine stroke direction without visual information. However, when it comes to the coordinate system used to assign the spatial relations to the stimulation, it remains poorly understood how the brain selects the appropriate system for passive touch. In the study reported here, we investigated whether hand orientation can determine coordinate assignment to ambiguous tactile patterns, whether observers can cognitively override any orientation-driven perspectives on touch, and whether the adaptation transfers across body surfaces. Our results demonstrated that the orientation of the hand in the vertical plane determines the perspective taken: an external perspective is adopted when the hand faces the observer and a gaze-centred perspective is selected when the hand faces away. Participants were then adapted to a mirror-reversed perspective through training, and the results revealed that this adapted perspective holds for the adapted surface and generalises to non-adapted surfaces, including across the body midline. These results reveal plasticity in perspective taking which relies on low-level postural cues (hand orientation) but also on higher-order somatosensory processing that can override the low-level cues.

MegaL – Mirror

The newly proposed Comprehensive in Vitro Proarrhythmia Assay (CiPA) offers a different strategy for defining proarrhythmic risk based upon a clear understanding of torsadogenic mechanisms beyond simply blocking hERG/IKr current. With CiPA, human iPSC-cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC-cardiomyocytes to provide the integrated drug response from multiple native human currents in a human-derived cellular preparation. However, according to Norman Stockbridge, MD, PhD, US Food and Drug Administration (US FDA) Division of Cardiovascular and Renal Products, these cardiomyocytes don't exactly mirror the density and proportions of ion channels found in normal human adult cardiomyocytes. Therefore, there is a need to further characterize the assay system and refine how to culture, use, and interpret data from these hiPSC-cardiomyocytes.

In past years, Costume Institute shows organized around designers such as Cristóbal Balenciaga, Chanel, Yves Saint Laurent, and Gianni Versace; and style doyenne like Diana Vreeland, Mona von Bismarck, Babe Paley, Jayne Wrightsman, Jacqueline Kennedy Onassis, Nan Kempner, and Iris Apfel have drawn significant crowds to the Met. The Costume Institute's annual Benefit Gala, co-chaired by Vogue editor-in-chief Anna Wintour, is an extremely popular, if exclusive, event in the fashion world; in 2007, the 700 available tickets started at $6,500 per person.[56]Exhibits displayed over the past decade in the Costume Institute include: Rock Style, in 1999,[57] representing the style of more than 40 rock musicians, including Madonna, David Bowie, and the Beatles; Extreme Beauty: The Body Transformed, in 2001, which exposes the transforming ideas of physical beauty over time and the bodily contortion necessary to accommodate such ideals and fashion;[58] The Chanel Exhibit, displayed in 2005,[59] acknowledging the skilled work of designer Coco Chanel as one of the leading fashion names in history; Superheroes: Fashion and Fantasy, exhibited in 2008,[60] suggesting the metaphorical vision of superheroes as ultimate fashion icons; the 2010 exhibit on the American Woman: Fashioning a National Identity, which exposes the revolutionary styles of the American woman from the years 1890 to 1940, and how such styles reflect the political and social sentiments of the time.[61] The theme of the 2011 event was "Alexander McQueen: Savage Beauty".[62] Each of these exhibits explores fashion as a mirror of cultural values and offers a glimpse into historical styles, emphasizing their evolution into today's own fashion world. On January 14, 2014, the Met named the Costume Institute complex after Anna Wintour.[63] The curator is Andrew Bolton.[64]

"Overall, our findings among African American women mirror those reported in the literature for white women, namely that high levels of alcohol intake - more than one drink per day - are associated with increased breast cancer risk," Troester said. "Alcohol is an important modifiable exposure, and women who are concerned about their risk of breast cancer could consider reducing levels of exposure." 041b061a72


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